Top 10 similar words or synonyms for pwwp

swirm    0.823285

ggdef    0.790437

rhogap    0.772198

baapp    0.770612

whep    0.763126

pseudokinase    0.760460

vwfa    0.756481

pryspry    0.755081

brct    0.752291

autoinhibitory    0.749243

Top 30 analogous words or synonyms for pwwp

Article Example
PWWP2A PWWP domain containing 2A is a protein that in humans is encoded by the PWWP2A gene.
DNA (cytosine-5)-methyltransferase 3A "DNMT3A" consists of three major protein domains: the Pro-Trp-Trp-Pro (PWWP) domain, the ATRX-DNMT3-DNMT3L (ADD) domain and the catalytic methyltransferase domain. The ADD domain serves as an inhibitor of the methyltransferase domain until "DNMT3A" binds to the unmodified lysine 4 of histone 3 (H3K4me0) for its "de novo" methylating activity. This protein thus seems to have an inbuilt control mechanism targeting histones only for methylation. Finally, the methyltransferase domain is highly conserved, even among prokaryotes!
Brpf1 Peregrin also known as bromodomain and PHD finger-containing protein 1 is a protein that in humans is encoded by the BRPF1 gene located on 3p26-p25. Peregrin is a multivalent chromatin regulator that recognizes different epigenetic marks and activates three histone acetyltransferases ("Moz", "Morf" and "Hbo1"). BRPF1 contains two PHD fingers, one bromodomain and one chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain.
PSIP1 LEDGF/p75 is a 60kDa, 530-amino-acid-long protein. The N-terminal portion of the protein consists of a PWWP domain, a nuclear localization sequence, and two copies of the AT-hook DNA binding motif. The C-terminal portion of LEDGF/p75 contains a structure termed the integrase-binding domain, which interacts with lentiviral integrase proteins as well as numerous cellular proteins. The N-terminal portion interacts strongly with chromatin, making LEDGF/p75 a constitutively nuclear protein. An isoform of the protein, LEDGF/p52, is produced by alternative splicing. LEDGF/p52 shares the N-terminal 325 amino acids of LEDGF/p75 but lacks the integrase-binding domain.
Brpf1 "Brpf1" gene is very conserved and has a critical role in different developmental processes. Zebrafish BRPF1, which is coordinated by its particular set of PWWP domains, mediates "Moz" -dependent histone acetylation and maintains "Hox" genes expression throughout vertebrate development, hence determines the proper pharyngeal segmental identities. Furthermore, "Brpf1" may not only has significant role for maintaining the anterior-posterior axis of the craniofacial skeleton, but also the dorsal-ventral axis of the caudal skeleton. Recent studies have shown that ablation of the mouse "Brpf1" gene causes embryonic lethality at embryonic day 9.5. Specifically, "Brpf1" regulates placenta vascular formation, neural tube closure, primitive hematopoiesis and embryonic fibroblast proliferation.