Top 10 similar words or synonyms for ggdef

lysm    0.817798

swirm    0.796745

pwwp    0.790437

gatase    0.768965

rhogap    0.768848

macpf    0.762714

enth    0.761258

domainprotein    0.760122

extracytoplasmic    0.755536

lrrnt    0.754763

Top 30 analogous words or synonyms for ggdef

Article Example
GGDEF domain In molecular biology, the GGDEF domain is a protein domain which appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Its function is to act as a diguanylate cyclase and synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria. Enzymatic activity can be strongly influenced by the adjacent domains. Processes regulated by this domain include exopolysaccharide synthesis, biofilm formation, motility and cell differentiation.
GGDEF domain Structural studies of PleD from "Caulobacter crescentus" show that this domain forms a five-stranded beta sheet surrounded by helices, similar to the catalytic core of adenylate cyclase.
Diguanylate cyclase Diguanylate cyclases are characterized by the conserved amino acid sequence motifs “GGDEF” (Gly-Gly-Asp-Glu-Phe) or “GGEEF” (Gly-Gly-Glu-Glu-Phe), which constitute the domain of the DGC active site. These domains are often found coupled to other signaling domains within multidomain proteins. Often, GGDEF domains with DGC activity are found in the same proteins as c-di-GMP-specific phosphodiesterase (PDE) EAL (Glu-Ala-Leu) domains.
Diguanylate cyclase Diguanylate cyclase participate in the formation of the ubiquitous second messenger, cyclic-di-GMP, involved in bacterial biofilm formation and persistence. The GGDEF domain was first identified in the regulatory protein, PleD of the bacterium "Caulobacter crescentus". It was later noted that numerous bacterial genomes encoded multiple proteins with a GGDEF domain. "Pseudomonas aeruginosa" PAO1 has 33 proteins with GGDEF domains, "Escherichia coli" K-12 has 19, and "Vibrio cholerae" O1 has 41. In the cell cycle of "Caulobacter crescentus", DGC PleD is known to control pole morphogenesis. In "Pseudomonas fluorescens" DGC WspR activity is hypothesized to be partially responsible for the wrinkly spreader (WS) phenotype. In "Pseudomonas aeruginosa", WspR has also been known to control autoaggregation.
Domain of unknown function The DUF naming scheme was introduced by Chris Ponting, through the addition of DUF1 and DUF2 to the SMART database. These two domains were found to be widely distributed in bacterial signaling proteins. Subsequently, the functions of these domains were identified and they have since been renamed as the GGDEF domain and EAL domain respectively.