Top 10 similar words or synonyms for solifenacin

asenapine    0.872264

fesoterodine    0.851255

tolterodine    0.843177

desvenlafaxine    0.841895

eszopiclone    0.831127

varenicline    0.826073

tegaserod    0.823210

duloxetine    0.818040

napadisylate    0.794554

arformoterol    0.791824

Top 30 analogous words or synonyms for solifenacin

Article Example
Solifenacin Solifenacin is a competitive cholinergic receptor antagonist, selective for the M receptor subtype. The binding of acetylcholine to these receptors, particularly M, plays a critical role in the contraction of smooth muscle.
Solifenacin Peak plasma concentrations are reached 3 to 8 hours after absorption from the gut. In the bloodstream, 98% of the substance are bound to plasma proteins, mainly acidic ones. Metabolism is mediated by the liver enzyme CYP3A4 and possibly others. There is one known active metabolite, 4"R"-hydroxysolifenacin, and three inactive ones, the "N"-glucuronide, the "N"-oxide and the 4"R"-hydroxy-"N"-oxide. The elimination half-life is 45 to 68 hours. 69% of the substance, both in its original form and as metabolites, are excreted renally and 23% via the feces.
Solifenacin Solifenacin (INN, trade name Vesicare) is a medicine of the antimuscarinic class and was developed for treating contraction of overactive bladder with associated problems such as increased urination frequency and urge incontinence. It is manufactured and marketed by Astellas, GlaxoSmithKline and Teva Pharmaceutical Industries.
Solifenacin Solifenacin is contraindicated for people with urinary retention, gastric retention, uncontrolled or poorly controlled closed-angle glaucoma, severe liver disease (Child-Pugh class C), and hemodialysis.
Solifenacin Long QT syndrome is not a contraindication although solifenacin, like tolterodine and darifenacin, binds to hERG channels of the heart and may prolong the QT interval. This mechanism appears to be seldom clinically relevant.