Top 10 similar words or synonyms for polyphenylalanine

polycysteine    0.769785

polytriptophane    0.754989

polyvaline    0.747622

polyisoleucine    0.744073

polyasparagine    0.728917

polyleucine    0.724516

polythreonine    0.721258

polypeptoids    0.718719

oligoarginine    0.703722

polyserine    0.685889

Top 30 analogous words or synonyms for polyphenylalanine

Article Example
J. Heinrich Matthaei J. Heinrich Matthaei (born 4 May 1929) is a German biochemist. He is best known for his unique contribution to solving the genetic code on 15 May 1961. Whilst a post-doctoral visitor in the laboratory of Marshall Warren Nirenberg at the NIH in Bethesda, Maryland, he discovered that a synthetic RNA polynucleotide, composed of a repeating uridylic acid residue, coded for a polypeptide chain encoding just one kind of amino acid, phenylalanine. In scientific terms, he discovered that polyU codes for polyphenylalanine and hence the coding unit for this amino acid is composed of a series of Us or, as we now know the genetic code is read in triplets, the codon for phenylalanine is UUU. This single experiment opened the way to the solution of the genetic code. It was for this and later work on the genetic code for which Nirenberg shared the Nobel Prize for Medicine and Physiology. In addition, Matthaei and his co-wokers in the following years published a multitude of results concerning the early understanding of the form and function of the genetic code.
Nirenberg and Matthaei experiment At 3 am on May 27 Matthaei used phenylalanine for the "hot" test tube. After an hour, the control tubes showed a background level of 70 counts, whereas the hot tube showed 38,000 counts per milligram of protein. The experiment showed that a chain of the repeated uracil bases produced a protein chain made of one repeating amino acid, phenylalanine. Therefore, polyU coded for polyphenylalanine, consistent with UUU coding for phenylalanine. At the time the number of bases per codon could not be determined. The two kept their breakthrough a secret from the larger scientific community until they could complete further experiments with other strands of synthetic RNA (such as Poly-A) and prepare papers for publication. Using the three-letter poly-U experiment as a model, the research team discovered that AAA (three adenosines) was the code word or "codon" for the amino acid lysine, and CCC (three cytosines) was the code word for proline. They also discovered that by replacing one or two units of a triplet with other nucleotides, they could direct the production of other amino acids. They found, for example, that a synthetic RNA GUU codes for a valine to be added to a developing amino acid chain.