Top 10 similar words or synonyms for polyleucine

polyglycine    0.799412

polyisoleucine    0.790197

polyasparagine    0.788405

polythreonine    0.785499

polyserine    0.777527

polytryptophan    0.773931

polyvaline    0.753121

homopolypeptides    0.750921

polyaspartamide    0.743047

polylysines    0.728466

Top 30 analogous words or synonyms for polyleucine

Article Example
Asymmetric nucleophilic epoxidation Aryl alkyl ("E")-enones have been epoxidized with high enantioselectivity using stoichiometric zinc peroxide systems. Polyleucine may be used with these substrates as well; when an existing stereocenter in the substrate biases the sense of selectivity of the epoxidation, polyleucine is able to overcome this bias.
Juliá–Colonna epoxidation Silica-grafted polyleucine has been shown to effectively catalyze epoxidation of α,β-unsaturated aromatic ketones. The silica graft allows for the catalyst to be easily recovered with only mild loss of activity and is particularly useful for scale-up reactions.
Juliá–Colonna epoxidation The poly-leucine strands demonstrate enzyme-like kinetics with a first-order dependence on and eventual saturation with both the hydroperoxide anion (K= 30 mM) and the olefin substrate (K=110 mM.) Kinetic study suggests that the reaction proceeds by random steady-state formation of a ternary (polyleucine+hydroperoxide anion+olefin) complex. Both substrates must bind prior to reaction, and while either may bind first, initial hydroperoxide binding is kinetically preferred. The rapid equilibrium enabling complex formation is followed by the rate-limiting formation of the peroxide enolate (Figure 3).
Juliá–Colonna epoxidation All of the reactants associate with the polyleucine catalyst prior to reaction to form the hydroperoxide enolate intermediate. The catalyst orients the reactants and, even more significantly, the peroxide enolate intermediate by a series of hydrogen bonding interactions with the four N-terminal amino groups in the poly-leucine α-helix. While other models have been proposed, computations by Kelly et al. have suggested that the NH-2, NH-3, and NH-4 form an isosceles triangle available for hydrogen bonding as an intermediate-stabilizing oxyanion hole. While olefin binding to either the "endo" or "exo" face of the helix is sterically allowed, only "endo" binding orients the NH-4 group to bind with the hydroperoxide moiety allowing for hydroxide displacement in the final reaction step (Figure 4).