Top 10 similar words or synonyms for fabh

fabf    0.858196

fabd    0.852078

fabz    0.837867

fabl    0.821368

fabg    0.813004

fabb    0.810908

accabcd    0.810363

bktb    0.797206

ketothiolase    0.797077

phab    0.788070

Top 30 analogous words or synonyms for fabh

Article Example
Beta-ketoacyl-(acyl-carrier-protein) synthase III Crystal structures of FabH have been reported from "Mycobacterium tuberculosis",{ "Staphylococcus aureus", "Escherichia coli", and "Thermus thermophilus".
Beta-ketoacyl-(acyl-carrier-protein) synthase III Following the discovery that phomallenic acids isolated from a leaf litter fungus identified as "Phoma" sp. are inhibitors of the FabH/FabF. Wang "et al." recently reported their discovery from the soil bacterium "Streptomyces platensis" of a novel natural inhibitor of FabH with "in vivo" activity called platencin. These were found by screening 250,000 extracts of soil bacteria and fungi, demonstrating the viability of bio-prospecting. While a potentially useful antibiotic in its own right, it has now been shown that platensimycin is not specifically active on mtFabH.
Beta-ketoacyl-ACP synthase Recent efforts in bioengineering include engineering of FAS proteins, which includes beta-ketoacyl-ACP synthase domains, in order to favor the synthesis of branched carbon chains as a renewable energy source. Branched carbon chains contain more energy and can be used in colder temperatures because of their lower freezing point. Using E. coli as the organism of choice, engineers have replaced the endogenous FabH domain on FAS, which favors unbranched chains, with FabH versions that favor branching due to their high substrate specificity for branched acyl-ACPs.
Beta-ketoacyl-(acyl-carrier-protein) synthase III This enzyme participates in fatty acid biosynthesis. β-Ketoacyl-acyl-carrier-protein synthase III is involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The role of FabH in fatty acid synthesis has been described in "Streptomyces glaucescens", "Streptococcus pneumoniae", and "Streptomyces coelicolor".
Beta-ketoacyl-ACP synthase The different types of beta-ketoacyl-ACP synthases in type II FAS are called FabB, FabF, and FabH synthases. FabH catalyzes the quintessential ketoacyl synthase reaction with malonyl ACP and acetyl CoA. FabB and FabF catalyze other related reactions. Given that their function is necessary for proper biological function surrounding lipoprotein, phospholipid, and lipopolysaccharide synthesis, they have become a target in antibacterial drug creation. Bacteria has the ability to adapt to its environment; bacteria can alter the phospholipid composition of its membrane to best suit the environment, so inhibiting this pathway is integral in disrupting bacterial proliferation. By studying Yersinia pestis, which causes bubonic, pneumonic, and septicaemic plagues, researchers have shown that FabB, FabF, and FabH can theoretically all be inhibited by the same drug due to similarities in their binding sites. However, such a drug has not yet been developed. Cerulenin, a molecule that appears to inhibit by mimicking the “condensation transition state” can only inhibit B or F, but not H. Another molecule, thiolactomycin, which mimics malonyl ACP in the active site, can ony inhibit FabB. Lastly, platensimycin also has possible antibiotic use due to its inhibition of FabF.