Top 10 similar words or synonyms for dbmal

concn    0.838557

dbdcb    0.746663

dbnpa    0.744084

bbit    0.743848

thps    0.735428

dcoit    0.708646

bugoil    0.701571

aloneand    0.701253

naopp    0.692069

ddac    0.691019

Top 30 analogous words or synonyms for dbmal

Article Example
CLOCK CLOCK protein has been found to play a central role as a transcription factor in the circadian pacemaker. In "Drosophila", newly synthesized CLOCK (CLK) is hypophosphorylated in the cytoplasm before entering the nucleus. Once in the nuclei, CLK is localized in nuclear foci and is later redistributed homogeneously. CYCLE (CYC) (also known as dBMAL for the BMAL1 ortholog in mammals) dimerizes with CLK via their respective PAS domains. This dimer then recruits co-activator CREB-binding protein (CBP) and is further phosphorylated. Once phosphorylated, this CLK-CYC complex binds to the E-box elements of the promoters of period (per) and timeless (tim) via its bHLH domain, causing the stimulation of gene expression of "per" and "tim". A large molar excess of period (PER) and timeless (TIM) proteins causes formation of the PER-TIM heterodimer which prevents the CLK-CYC heterodimer from binding to the E-boxes of "per" and "tim", essentially blocking "per" and "tim" transcription. CLK is hyperphosphorylated when doubletime (DBT) kinase interacts with the CLK-CYC complex in a PER reliant manner, destabilizing both CLK and PER, leading to the degradation of both proteins.