carbobenzyloxy - Synonyms of carbobenzyloxy | Antonyms of carbobenzyloxy | Definition of carbobenzyloxy | Example of carbobenzyloxy | Word Synonyms API

Top 10 similar words or synonyms for carbobenzyloxy

carboxybenzyl 0.852556

carbobenzoxy 0.819716

teoc 0.806742

aralkyoxycarbonyl 0.797953

tertiair 0.796876

cbz 0.780967

tertbutoxycarbonyl 0.776270

nboc 0.775469

dimethoxybenzyl 0.768483

benzyloxocarbonyl 0.766597

Article	Example
Amino acid N-carboxyanhydride	NCA's are precursors to amino acid homopolymers. Ephraim Katzir first used this method to synthesize poly-L-lysine from N-carbobenzyloxy-α-N-carboxy-L-lysine anhydride, followed by deprotection with phosphonium iodide.
Trovafloxacin	The key reaction in building the ring consists of 1,3-Dipolar cycloaddition of ethyl diazoacetate to N-Cbz-3-pyrroline to afford the pyrrazolidine (3). Pyrolysis results in loss of nitrogen and formation of the cyclopropylpyrrolidine ring. The stereochemistry of the ring simply reflects the thermodynamics, since "cis" ring fusion is by far the most stable arrangement, as is the "cis" configuration of the ester group. The ester is then saponified to the corresponding carboxylic acid (5). The acid undergoes a version of the Curtius rearrangement when treated with diphenylphosphoryl azide (DPPA) to afford the transient isocyanate (6). The reactive function adds t-BuOH from the reaction medium to afford the product as its tert-Butyloxycarbonyl protecting group derivative (7). Catalytic hydrogenation then removes the carbobenzyloxy protecting group to afford the secondary amine (8). In a standard quinoline reaction, this amine is then used to displace the more reactive fluorine at the 7-position in Ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (9).

Article

Example

Amino acid N-carboxyanhydride

NCA's are precursors to amino acid homopolymers. Ephraim Katzir first used this method to synthesize poly-L-lysine from N-carbobenzyloxy-α-N-carboxy-L-lysine anhydride, followed by deprotection with phosphonium iodide.

Trovafloxacin

The key reaction in building the ring consists of 1,3-Dipolar cycloaddition of ethyl diazoacetate to N-Cbz-3-pyrroline to afford the pyrrazolidine (3). Pyrolysis results in loss of nitrogen and formation of the cyclopropylpyrrolidine ring. The stereochemistry of the ring simply reflects the thermodynamics, since "cis" ring fusion is by far the most stable arrangement, as is the "cis" configuration of the ester group. The ester is then saponified to the corresponding carboxylic acid (5). The acid undergoes a version of the Curtius rearrangement when treated with diphenylphosphoryl azide (DPPA) to afford the transient isocyanate (6). The reactive function adds t-BuOH from the reaction medium to afford the product as its tert-Butyloxycarbonyl protecting group derivative (7). Catalytic hydrogenation then removes the carbobenzyloxy protecting group to afford the secondary amine (8). In a standard quinoline reaction, this amine is then used to displace the more reactive fluorine at the 7-position in Ethyl 1-(2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (9).