Top 10 similar words or synonyms for alnespirone

amineptine    0.918963

mirtazepine    0.912857

azaspirones    0.912823

rizatripan    0.911406

naratripan    0.901890

adrafinil    0.900867

alpidem    0.900624

ipsapirone    0.898814

zimelidine    0.897681

doxepine    0.896712

Top 30 analogous words or synonyms for alnespirone

Article Example
Alnespirone Alnespirone (S-20,499) is a selective 5-HT receptor full agonist of the azapirone chemical class. It has antidepressant and anxiolytic effects.
Pyrimidinylpiperazine The anxiolytics are also classified as azapirones due to the azaspirodecanedione moiety in their structures. 1-PP is a common metabolite of most or all of the listed agents. Alnespirone, binospirone, and enilospirone, despite being azapirones, are not piperazines and therefore do not metabolize to 1-PP, and while perospirone and tiospirone are piperazines, they are instead benzothiazole-substituted piperazines and do not metabolize to 1-PP either.
Azapirone 5-HT receptor partial agonists have demonstrated efficacy against depression in rodent studies and human clinical trials. Unfortunately, however, their efficacy is limited and they are only relatively mild antidepressants. Instead of being used as monotherapy treatments, they are more commonly employed as augmentations to serotonergic antidepressants like the SSRIs. It has been proposed that high intrinsic activity at 5-HT postsynaptic receptors is necessary for maximal therapeutic benefits to come to prominence, and as a result, investigation has commenced in azapirones which act as 5-HT receptor full agonists such as alnespirone and eptapirone. Indeed, in preclinical studies, eptapirone produces robust antidepressant effects which surpass those of even high doses of imipramine and paroxetine.